LYMPHOID NEOPLASIA Inhibition of aurora kinases for tailored risk-adapted treatment of multiple myeloma
نویسندگان
چکیده
Dirk Hose,1,2 Thierry Rème,3,4 Tobias Meissner,1 Jérôme Moreaux,3,4 Anja Seckinger,1 Joe Lewis,5 Vladimir Benes,5 Axel Benner,6 Michael Hundemer,1 Thomas Hielscher,6 John D. Shaughnessy Jr,7 Bart Barlogie,7 Kai Neben,1 Alwin Krämer,1 Jens Hillengass,1 Uta Bertsch,1 Anna Jauch,8 John De Vos,3,4 Jean-François Rossi,3,4 Thomas Möhler,1 Jonathon Blake,5 Jürgen Zimmermann,5 Bernard Klein,3,4 and Hartmut Goldschmidt1,2
منابع مشابه
Inhibition of aurora kinases for tailored risk-adapted treatment of multiple myeloma
Genetic instability and cellular proliferation have been associated with Aurora-kinase expression in several cancer entities, including multiple myeloma. Therefore, the expression of , and was determined by Affymetrix DNA-microarrays in 784 samples Aurora-A -B -C including two independent sets of 233 and 345 CD138-purified myeloma-cells from previously untreated myeloma-patients. Chromosomal ab...
متن کاملInhibition of aurora kinases for tailored risk-adapted treatment of multiple myeloma.
Genetic instability and cellular proliferation have been associated with aurora kinase expression in several cancer entities, including multiple myeloma. Therefore, the expression of aurora-A, -B, and -C was determined by Affymetrix DNA microarrays in 784 samples including 2 independent sets of 233 and 345 CD138-purified myeloma cells from previously untreated patients. Chromosomal aberrations ...
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A paucity of validated kinase targets in human multiple myeloma has delayed clinical deployment of kinase inhibitors in treatment strategies. We therefore conducted a kinome-wide small interfering RNA (siRNA) lethality study in myeloma tumor lines bearing common t(4;14), t(14;16), and t(11;14) translocations to identify critically vulnerable kinases in myeloma tumor cells without regard to prec...
متن کاملTargeting aurora kinases as therapy in multiple myeloma.
The aurora kinases facilitate transit from G2 through cytokinesis and, thus, are targets in cancer therapy. Multiple myeloma (MM) is a malignancy characterized by genetic instability, suggesting a disruption of checkpoints that arrest cells at G2M when injury to the mitotic machinery occurs. Since deficient checkpoints would prevent cell cycle arrest and may render cells susceptible to apoptosi...
متن کاملThe centrosome index is a powerful prognostic marker in myeloma and identifies a cohort of patients that might benefit from aurora kinase inhibition.
Centrosome amplification is common in myeloma and may be involved in disease pathogenesis. We have previously derived a gene expression-based centrosome index (CI) that correlated with centrosome amplification and was an independent prognostic factor in a small cohort of heterogeneously treated patients. In this study, we validated the prognostic significance of the CI in 2 large cohorts of pat...
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